140 Clinical characteristics of systemic sclerosis patients with anti-NOR90 antibodies

Anti-NOR90 antibodies are usually found in patients with systemic sclerosis (SSc); however, their clinical relevance remains obscure. We previously developed an enzyme-linked immunosorbent assay (ELISA) for measuring them to investigate the features of anti-NOR90 antibodies. As we additionally obtained antibody-positive serum samples after our previous research, reexamined significance Serum from 1,296 various conditions Nagoya University Hospital were included. assayed by ELISA using recombinant protein produced vitro transcription/translation. Eight (0.6%) had One patient diffuse cutaneous SSc, 5 limited SSc (lcSSc), and 2 Raynaud’s disease positive more frequently scleroderma-spectrum disorders (SSDs) than without SSDs (8/328 vs 0/968, P<0.00002) (6/259 0/544, P<0.002) autoimmune rheumatic cohort. Among 6 anti-NOR90-positive 4 cancer 3 interstitial lung (ILD). Statistically significant difference prevalence neither nor ILD was between -negative patients, lcSSc (3/5 28/147, P<0.058) relatively detected patients. Further research a great number sera antibodies, especially is needed elucidate